B12 injection treatment advice While your doctor may prescribe a specific regimen that suits your exact medical needs, the guideline recommended treatment for peripheral neuropathy using vitamin B12 injections is as follows: Daily injections of 1,000mcg for at least five days Followed by 1,000mcg injections administered once per week, for a period of five weeks Eventually, injections may be reduced to just 1000mcg, once a month, but you may be required to administer them for the rest of your life Most injection regimens are tailored to the individual since people absorb and utilize the vitamin differently
This titration schedule exists specifically to minimize gastrointestinal side effects
Mills JL, Molloy AM, Reynolds EH
These findings support the rationale for frequent, low-dose supplementation strategies in healthy individuals, while also emphasising the need for personalised approaches in those with malabsorption syndromes (Bor et al., 2010)