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Due to its acidic nature, localized burning or welt-like reactions have been observed in some models following subcutaneous placement
PMCID: PMC3764915
MET activation is thus involved in brain plasticity, as suggested by the fact that HGF administration on hippocampal slices enhances the phosphorylation of the glutamatergic NMDA receptor subunit GluN1, augments the NMDA-mediated currents, and increases the amplitude of long-term potentiation (LTP) induced by elevated neuronal activity (Kato et al., 2012)
In conclusion, studying these molecular pathways might open the way for early alleviation of the intestinal damage and the development of various agent plans to attenuate MTX-mediated intestinal injury
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