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Educational notice: This article discusses peptide identity, pigmentation biology, regulated afamelanotide research, clinical evidence, adverse effects and UK regulation

Patients with Known or Suspected Mitochondrial Disease Valproic acid is contraindicated in patients known to have mitochondrial disorders caused by POLG mutations and children under two years of age who are clinically suspected of having a mitochondrial disorder [see Contraindications (4)]

Some patients stay on a lower maintenance dose long-term, which keeps monthly cost down