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Although no human studies exist, the researchers noted that mice treated with SLU-PP-332 did not exhibit severe side effects

Community sources occasionally describe transient mood lift in the first 1-2 weeks, sometimes attributed to GH-axis effects

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While we have observed a direct detrimental effect of a cholesterol-enriched diet on islet GLP-1R cAMP outputs, we cannot rule out that the reduced receptor capacity to lower blood glucose levels following cholesterol loading might encompass further negative effects of high cholesterol on GLP-1R downstream signalling