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Studies have documented the presence of BFRs in the environment, food, drinking water, inhaled dust, and the human body [429, 430]

Compounding serves legitimate medical needs, particularly when: A patient needs a dose strength not commercially available A patient is allergic to an inactive ingredient in the commercial product A patient needs a different delivery method (e.g., liquid instead of pill) Commercial supply shortages create access issues Compounded drugs are not FDA-approved as finished products

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Enter desired dose, vial amount, and reconstitution volume to estimate mL to draw and syringe units