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The hallmark features of the subtype include higher expression of Ki67 (hence higher proliferation rate), lower expression of PR, and in some cases, positive status of HER2 and ER, a more aggressive phenotype with higher chances of early relapse, poor prognosis, lower survival rate, lymph node involvement, and metastasis (99)

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Specifically, they reported that higher levels of HO-1 expression correlate with an increase in TFR expression and a decrease in SLC40A1 expression, ultimately leading to iron accumulation (245)

Insulin-like Growth Factor Receptor 1 (IGF1R) Gene Copy Number Is Associated With Survival in Operable NonSmall-Cell Lung Cancer: A Comparison Between IGF1R Fluorescent In Situ Hybridization, Protein Expression, and mRNA Expression