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While AEs associated with these agents have been investigated 19,36,37 , our analysis reveals critical gaps in understanding their NAEs given the central nervous system penetration and expanding indications of GLP-1 RAs

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10.1016/j.biopsych.2008.03.004 Biol Psychiatry

(And you can even get it on Ro if appropriate, of course.) In late December 2025, the FDA officially approved the Wegovy pill for the following indications: To reduce excess body weight and maintain weight reduction long term in Adults with obesity Adults with overweight and at least one weight-related medical condition (e.g