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Individuals with certain medical conditions or health concerns, such as kidney disease, liver disease, certain blood disorders, or allergies to specific vitamins, may need to avoid or modify the therapy

However, the effectiveness of oral supplements may not effectively raise blood Glutathione levels because Glutathione can be broken down in the digestive tract

This can manifest as irregular menstrual cycles, anovulation, difficulty getting pregnant, or miscarrying

Procedures to limit the continuing absorption of the drug must be readily performed since the hepatic injury is dose dependent and occurs early in the course of intoxication