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Efficacy of Once-Weekly Semaglutide versus Placebo as Add-on to Insulin in Subjects with Type 2 Diabetes (SUSTAIN 5): A Randomized, Double-Blind, Placebo-Controlled, Phase 3a Trial

Semaglutide: Albumin-Binding Powerhouse Semaglutide is a second-generation GLP-1 receptor agonist originally developed for type 2 diabetes and now widely used for weight loss

However, certain physiological changes associated with GLP-1 receptor agonistsincluding reduced fluid intake, weight loss, and metabolic shiftsmay theoretically increase kidney stone risk in predisposed individuals

The capsules should be taken for a period of at least three months in order to optimize each individual phase of the spermatogenesis