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In addition to the current clinical interventions available to manage APAP hepatotoxicity, including gastrointestinal track decontamination, NAC administration and liver transplantation, the improvement of mitophagy may stand as a promising novel approach for the management of APAP hepatotoxicity

Based on the aforementioned studies, natural plant polysaccharides exert anti-oxidative stress effects by upregulating the levels of antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT), while downregulating the levels of malondialdehyde (MDA) as an oxidizing agent

in cases of weakened immunity