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Confirmed overall response rate was 20% (95% CI = 11, 31) in the selumetinib arm compared to 5% (95% CI = 2, 13) for those receiving placebo (p = 0.011)

Simultaneously, this decreasing pool of alive cells keeps secreting glutathione until, after ~300 h, the probability of replicating is very close to the probability of dying and very few alive cells are left in the population

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The 3-methylcrotonyl-CoA is the product of isovaleryl-CoA dehydrogenase (IVD) which catalyzes the prior reaction in leucine catabolism