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These mechanisms differ fundamentally from antihypertensive drugs, meaning GLP-1 agents do not directly lower blood pressure through vasodilation or diuresis

Abstract In the SELECT cardiovascular outcomes trial, semaglutide showed a 20% reduction in major adverse cardiovascular events in 17,604 adults with preexisting cardiovascular disease, overweight or obesity, without diabetes

Across excitatory neuronal types, the excitatory-associated cytoskeletal genes (DBN1, TUBA8, PALM and NEFM) were co-enriched in layer 3/4 RAR-related orphan receptor b (RORB) and THEMIS-expressing excitatory neurons, both subclasses of intratelencephalic (IT) neurons (Fig

As these drugs become more widely used, the demographic profile of regular alcohol consumers might shift