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Preliminary findings also suggest improvement in symptoms of chronic fatigue syndrome (22) and physical performance in patients undergoing dialysis for end-stage renal disease (9) , but data on benefits against fatigue associated with multiple sclerosis are inconclusive (21)

In a rodent model, a novel GLP-1R/GIPR/GCGR triple agonist, SAR441255, has been shown to promote weight loss and the maintenance of healthy blood glucose levels and is superior to the GLP-1R/GCGR dual agonist (Bossart et al., 2022)

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