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It describes the facial changes that can accompany rapid weight loss when using medications like Ozempic or another version of the same drug (generic name semaglutide) FDA-approved for weight-loss treatment

Ozempic activates GLP-1 receptors to enhance insulin production, reduce glucagon secretion, delay gastric emptying, promote satiety, and aid in weight reduction

Why it matters Strengthens the cardiometabolic positioning of GLP-1 receptor agonists and dual GIP/GLP-1 agonists

Importantly, because MOTS-c is an endogenous peptide that the body naturally produces, it is theoretically less likely to trigger immune responses or off-target effects compared to completely foreign molecules