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Romeo B, Choucha W, Fossati P, Rotge JY

15-21%).[1][53] Enhanced metabolism via glucagon, reducing fat while preserving muscle.[3][54] Clinical Advantages: Superior hepatic benefits for NAFLD.[4][55] Potential for broader cardiometabolic protection.[1][56] Pharmaceutical Benefits: Once-weekly dosing for compliance.[1][10] Customizable in compounding for trial support.[6][57] Future Outlook Emerging trends include expanded Phase 3 trials (TRIUMPH series) with results expected in late 2025, focusing on long-term safety, cardiovascular outcomes, and NAFLD.[26][58] Ongoing research explores combinations with other agents and applications in precision medicine for obesity subtypes.[1][59] Conclusion Retatrutide represents an innovative frontier for compounding pharmacies, offering a triple-agonist approach to metabolic therapy

doi:10.3390/ijms27031409 Comparison of oral semaglutide (Wegovy) and orforglipron (Foundayo) for the treatment of obesity and overweight

Lifestyle factorsmeal composition, physical activity, sleep quality, stressaccount for another 30-40%