Common side effects (5% or more of patients) Nausea Diarrhea Vomiting Constipation Abdominal pain Reduced appetite Indigestion or acid reflux Fatigue Mild injection site reactions (redness, itching, or bruising) Serious side effects (rare but require immediate medical attention) Pancreatitis: severe, persistent abdominal pain that may radiate to the back, often with nausea or vomiting Gallbladder problems: upper right abdominal pain, fever, jaundice, or unusual stool color Severe allergic reactions: rash, swelling of the face or throat, difficulty breathing Kidney issues: often related to dehydration from prolonged vomiting or diarrhea Diabetic retinopathy complications in patients with pre-existing diabetic eye disease (a known risk specific to rapid A1C reduction) Severe hypoglycemia when used in combination with insulin or sulfonylureas Increased heart rate at rest Boxed warning: Semaglutide caused thyroid C-cell tumors in animal studies
NNMT inhibitors show promise in suppressing obesity and increasing metabolic health
Antidepressants that modulate both serotonin and norepinephrine, including duloxetine and venlafaxine, appear to exert no significant influence on glucose regulation mechanisms [163]
With existing drugs, youre going to get maybe 5% to 10% weight reduction, sometimes not even that, said Dr
