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Therefore, to further dissociate the effects of GSH and NRF2 on lipid abundance and assess if NRF2 activation alone mimics the effects of liver-specific Gclc deletion, we treated Gclc WT mice with CDDO-methyl (CDDO-Me), a form of bardoxolone with increased bioavailability

These include: Numbness or tingling in the hands and feet Difficulty walking Balance problems Mood changes, such as depression These symptoms affect the nervous system

We view this structure as an excellent model for Zur-regulated PyrC2 given the high (50%) sequence identity and the presence of the same site 1 Gln substitution that is found in the P

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