About 95% of the bodys creatine is stored in the skeletal muscles, primarily as phosphocreatine, and the other 5% in the brain and other parts of the body
The absorption pathway is permanently compromised
The lamina propria also contains connective tissue scaffolds, enteric nerves, fibroblasts, and smooth muscle cells ( In addition to its expression in the pancreas, proglucagon is also produced in enteroendocrine L cells throughout the small and large intestine (Jorsal et al., 2018)
Notably, synbiotic treatment demonstrated superior effects by restoring gut microbiota balance, increasing beneficial Lactobacillus species, and reducing harmful bacteria (e.g., coliform and staphylococci), suggesting that the combined impact on gut health and brain function was more potent than the individual therapies