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M., Weigand, G

doi: 10.1016/j.cell.2013.12.010 48 YaoX.ZhangY.HaoJ.DuanH

They usually contain seven conserved Cys residues, five in the N-terminal domain which include four iron-sulfur (Fe-S) cluster ligands and a catalytic residue and two in the GRX-like domain (Figure 2 and Supplementary Table 2)

We also revealed that GPX4 knockdown or low-dose treatment with GPX4-targeting inhibitors effectively reduces the chemoresistance of EBV-positive NPC cells, providing a potential therapeutic target for the treatment of chemoresistant tumors