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3-[5-(2-Ethyl carbonyl-1-methylvinoxy)1-methyl-1 H-indol-3-yl]but-2-enoic acid ethyl ester, referred to as MIBE, is a synthetic compound that exhibits dual antagonism of ER and GPER by blocking GPER-mediated transactivation of EGFR and inhibiting ERK phosphorylation [279]

Article last reviewed: April 2, 2026 | Next scheduled review: July 2, 2026 About the Author Lawrence Winnerman Founder of Peptidings.com

The GSH/GSSG ratio was calculated as the GSH-GSSG signal divided by the GSSG/2 signal

Based on clinical studies: 25-55% reduction in wrinkle depth/volume after 8-12 weeks, 70% increase in skin elasticity, 28% increase in collagen density