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Under persistent hyperglycemic conditions, proteins and lipids undergo non-enzymatic glycation to form AGEs which bind to their receptors and activate multiple damaging pathways including PARP-mediated oxidative stress, glutamate accumulation, and tissue injury [64]

JAMA 327(2):138150 Sorli C, Harashima SI, Tsoukas GM, Unger J, Karsbl JD, Hansen T et al (2017) Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial

Standard Maintenance Dose (Red Pen - 0.5 mg) Increase to 0.5 mg once per week, which is the usual long-term dose for many patients

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