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CAFs and TAMs actively supply metabolites such as lactate, glutamine, and fatty acids, providing CSCs with alternative fuel sources that shield them from metabolic stress and apoptosis
Research in preclinical models has explored its role in NNMT inhibition, NAD+ metabolism, and cellular energetics (pmc.ncbi.nlm.nih.gov, pubmed.ncbi.nlm.nih.gov)
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