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In primary rat pituitary cell culture, TNF- can induce a rapid increase in intracellular free calcium concentration, and the time course is highly consistent with the increase in prolactin secretion, suggesting that the calcium signaling pathway plays a key downstream effect in the process of inflammatory factors directly acting on prolactin-secreting cells

found that in vitro decidualization of HESCs, confirmed by upregulated expression of PRL , IGFBP1 and FOXO1 , resulted in an increase in expression of senescence markers p21 and p53 , suggesting that decidualization may promote cellular senescence (Kusama et al., 2021)

Clinical research has shown that high doses of NAC given intravenously can decrease prothrombin time and increase blood loss during surgery compared to placebo [66]

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