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10.1016/j.cmet.2012.03.005 [DOI] [PMC free article] [PubMed] [Google Scholar] 56.Jubaidi FF, Zainalabidin S, Mariappan V, Budin SB

doi: 10.1016/j.jchromb.2024.124187

While developing tricyclic novel compounds, adding methyl at R and 2-cyano benzyl at R 1 position enhances the inhibition potency against DPP-4 significantly with IC 50 of 10.6 nM [comparing with alogliptin (IC 50 7.6 nM)]