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From the isolation of intestinal crypt organoids to their maintenance and subsequent seeding into a monolayer for experimental use, procedures were conducted following protocols outlined in stem cell technology literature

Vedolizumab (a humanized anti-47 monoclonal antibody) exhibits gut selectivity [303, 304, 306], induces and maintains remission efficacy [307, 308], and is particularly suitable for patients who have failed anti-TNF therapy, with subcutaneous administration showing comparable efficacy and safety to intravenous delivery [309]

Kumar S: Occupational, environmental and lifestyle factors associated with spontaneous abortion

Kroemer G, Galluzzi L, Brenner C