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The most frequently observed adverse effects associated with CagriSema were gastrointestinal

Considering the low yield of expressed protein with pAcF incorporated, we engineered pCNFRS to improve the incorporation of pAcF by introducing a quadruple mutation H283T/P284S/M285D/D286V (TSDV) located at the anticodon recognition domain that was proved useful in pAzFRS for improving the incorporation of (p-azido-phenylalanine) pAzF 28

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