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Here, the framework suggests cautious re-evaluation focused on assay standardization, context-specific endpoints, and direct pharmacologic modulation rather than continued reliance on observational correlations

And of course, your weight should be optimized and ideally stable for six months to a year before surgery to ensure a consistent and enduring aesthetic outcome from surgery

And, the issue here is that once you reach a target body weight, the indication for the medication should, in theory, not be present anymore