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Human trials demonstrate that two weeks of glutathione supplementation (1g daily) significantly reduces exercise-induced blood lactate elevation and prevents the decrease in intermuscular pH that typically occurs during intense physical activity
Immunofluorescence analysis corroborated these findings, showing significant reduction of DLAT aggregates with DEX intervention (Figure 8)
doi: 10.1016/0140-6736(92)91589-Z 240 EpsteinFH
In contrast to their expectations, the results have shown that daily supplementation with vitamin C and vitamin A for 4 weeks not only failed to improve the insulin responsiveness but also decreased the expression of ROS-sensitive transcriptional regulators, molecular mediators of ROS defense (SOD 1 and 2, glutathione peroxidase) [90]
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