Despite promising preclinical data, the critical transition of Cu-MOFs and similar nanoplatforms to clinical application faces hurdles, including scalable fabrication, long-term biodistribution studies, and a comprehensive understanding of potential off-target cuproptosis
The pathogenesis of cerebral circulation disorders caused by chronic hyperglycemia is complex and includes mitochondrial dysfunction, neuroinflammation, impaired neurotransmitter systems, and vascular pathologies that lead to cognitive impairment, neurodegeneration, loss of synaptic plasticity, brain aging, and dementia [27]
Furthermore, our ligand-receptor analysis indicates that the inflammatory phenotype is directly mediated via cellular interactions between adipocytes and immune cells, as we found a decrease in the interaction strength in p53 KO mice
The most significant trend to watch is the increasing integration of traditional medicine with modern nutraceuticals, which could unlock new segments and accelerate adoption