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Leonardi C, Matheson R, Zachariae C, Cameron G, Li L, Edson-Heredia E,

- Then, in ATTAIN-MAINTAIN, those same individuals were randomized for another 52 weeks to once daily orforglipron vs placebo, on top of lifestyle support

It should not be expected to reverse severe osteoarthritis, regrow advanced cartilage loss, correct major joint deformity, heal a complete tendon rupture without appropriate orthopedic management, or replace surgery when surgery is clearly indicated

The use of some of these medications for weight loss, such as Ozempic for weight loss and Wegovy for weight loss outside of approved BMI ranges, has led to serious shortages