soul trial oral semaglutide cardiovascular outcomes soul trial results 2025 nejm Heart disease is the #1 cause of death in type 2 diabetes — and for the first Post hoc analysis of SUSTAIN

12 However, tirzepatide at a 15-mg dose was administered for only 20 weeks, an inadequate duration to attain a plateau for weight reduction in SURPASS-1 and SURPASS-2

Common Gastrointestinal Side Effects Besides nausea, other digestive complaints frequently reported in clinical trials include: Vomiting: Often accompanies severe nausea, more common at higher doses

Seek urgent medical attention for sudden severe headache, headache with fever or visual changes, persistent vomiting, or symptoms suggesting pancreatitis or severe dehydration

In-Use Storage: Once opened, you can keep the vial/pen at room temperature (below 30C) or in the refrigerator for up to 30 days