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This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Smeyne and Smeyne, 2013)

- La semaglutida oral es eficaz, segura y bien tolerada en pacientes con DM2, incluso en aquellos con ERD, con los beneficios propios de esta familia de frmacos, lo que puede facilitar la introduccin ms precoz de un arGLP-1 en el manejo de la DM2

In StatPearls (StatPearls Publishing, Treasure Island, FL, 2025)