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This is attributed to greater awareness of the drugs and to doctors' increased familiarity with prescribing them

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As a matter of fact, ALA is able to prevent the upregulation of intercellular adhesion-molecule-1 (ICAM-1) and vascular cell adhesion-molecule-1 (VCAM-1) in tumor necrosis factor (TNF- )-stimulated brain and aortic endothelial cells in vitro [ 33 , 35 ]