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A multicenter, 16-week, double-blind, placebo-controlled study in children and adolescents with PWS and obesity found that liraglutide had no impact on BMI in children or adolescents after 16 weeks of treatment, nor was weight improved after 52 weeks on the drug compared to placebo

Combination effects

When you drink water, it has to filter down through your whole digestive system before it can be absorbed

The recurring methodological feature across these subliteratures is small effect sizes, variable replication, and operational endpoints (EEG patterns, behavioral scores, plasma hormone levels) that cannot, on their own, identify a target