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[58] Primarily through its impact on phosphodiesterase, caffeine can improve several aspects of physical performance, including strength, speed, and endurance
Participants over the age of 18 with hypertensiondefined as seated systolic blood pressure (SBP) 140 mmHg and/or seated diastolic blood pressure (DBP) 90 mmHg at the screening visitwere eligible to participate
ArticlePubMedPMC 152
In turn, this inflammatory milieu, characterized by the production of inflammatory and pro-fibrotic cytokines, further exacerbates microvascular endothelial cell injury and apoptosis (174, 175), creating a vicious cycle that culminates in thrombosis, inflammation, and a myriad of clinical manifestations ranging from skin to parenchymal organs (174, 176)
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