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This is covered in detail in the maintenance section, but briefly: people who have established ketogenic metabolic adaptation while on semaglutide appear better positioned to maintain their weight loss after discontinuation than people who relied purely on drug-mediated appetite suppression

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Clinical trial data demonstrate that discontinuation of semaglutide leads to gradual weight regain in most patients, with studies showing approximately two-thirds of lost weight returning within one year of stopping treatment

Official 2026 PA Timeline Data for Semaglutide Washington States Office of the Insurance Commissioner published official plan-year 2024 prior authorization response time data on January 1, 2026