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Source: figure made with data from the American Diabetes Association Professional Practice Committee11 and from Montero et al.12 The management of patients with CKD and T2DM requires a global and comprehensive treatment that covers aspects associated with the progression of renal disease and the risk of developing cardiovascular complications

[DOI:10.1007/s12011-020-02268-8] [PMID] Shokrzadeh M, Mohammadpour A, Modanloo M, Hassani M, Barghi NG, Niroomand P

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These two studies pinpointed that the effects of cyst(e)ine depletion are not linear, but rather form an intertwined metabolic network to drive ferroptotic cell death