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PRDX6 selectively binds oxidized phospholipids, becomes membrane-associated, and executes coordinated membrane repair through reductive detoxification, iPLA 2 -mediated deacylation, and LPCAT-dependent reacylation with non-oxidized fatty acids

In some embodiments, the otic formulation or composition comprises between about 0.01% to about 1% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

We have previously shown that Os accumulation in ovarian cancer cells involves contributions from both passive diffusion and active transport mechanisms [17]

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