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Similar to the endothelial dysfunction in diabetes, the metabolic changes observed in microglia are mediated through signaling cascades involving mitogen-activated protein kinase (MPK), PI3K/Akt, and NF-B (Hsieh et al., 2019)

The Evidence: Randomized placebo-controlled studies demonstrate that Transcranial PBM significantly reduces the number of headache days per month by raising the brain's metabolic threshold and reducing cortical hyperexcitability [5]