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In a clinical trial of more than 3,000 adults with obesity, participants who received the highest dose of orforglipron, 36 milligrams, lost 11.2% of their body weight -- about 25 pounds on average -- over more than 16 months

Although animal studies have shown a possible risk of thyroid tumors, this has not been confirmed in humans

If cost is a central factor, the Medicare program may have a big impact

I often see this work well for individuals who are already doing many of the right thingseating well, moving their bodies, working on sleep and stressbut still feel weight-loss resistant. This slower, gentler dosing strategy can be a good fit for people with a history of GI issues like IBS or chronic constipation or who tend to be sensitive to medications in general