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Immunostained cells were imaged on an SP8 confocal microscope and acquisition software (LAS X, Leica Microsystems)

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6J-O) demonstrated that Keap1 protein expression was significantly upregulated, while Nrf2 and GPX4 protein levels were downregulated in DSS-treated colonic tissues versus the Control group

The key clinical message is that no safety signal for increased suicidality was observed