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The ustekinumab biosimilar market (Stelara reference, multiple approved biosimilars) is an example of a dermatology/gastroenterology biologic with strong biosimilar development, but it faces the competing next-generation branded challenge: AbbVies Skyrizi (risankizumab) has been actively marketed to physicians as a superior alternative to Stelara, complicating biosimilar market share projections

Many patients notice reduced appetite and early satiety within the first week of treatment

Some patients develop gastrointestinal symptoms only after multiple dose escalations, suggesting cumulative tolerance thresholds

Please consult your own physician or appropriate health care provider about the applicability of any opinions or recommendations with respect to your own symptoms or medical conditions as these diseases commonly present with variable signs and symptoms