Listen to Your Body: Start with a moderate dose and adjust based on your personal wellness goals
In the db/db mouse model, local administration of GLP1RAs reverses diabetes-induced downregulation of GLAST (glutamate-aspartate transporter), reduces extracellular glutamate accumulation, and activates anti-apoptotic signalling pathways such as Bcl2 and AKT, thereby inhibiting the expression of apoptotic factors such as iNOS, FasL, and caspase8 [62, 64]
Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, Hardt-Lindberg S, Hovingh GK, Kahn SE, Kushner RF, Lingvay I, Oral TK, Michelsen MM, Plutzky J, Torne CW, Ryan DH (2023) Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes
Compounded versions offer cost accessibility and provider flexibility, though clinical efficacy depends on pharmaceutical quality and adherence