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The nitric oxide (NO) donor GSNO (facilitating S-nitrosylation of GSSH) completely abolished GSSSG-dependent cyt c reduction (Fig

2017 Cell study used 5 mg/kg intraperitoneal injection three times per week in aged mice, with treatment periods of several weeks the three-times-weekly dosing suggests the peptide maintains sufficient functional concentrations for at least 48-72 hours per dose (PMID: 28340339)