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Hepatocytes are responsible for the synthesis of glucose (gluconeogenesis), albumin, other plasma proteins, cholesterol and bile acids, the metabolism of drugs and toxins, and the oxidation of fatty acids

With regard to kidney protection, in the doxorubicin (DOX) induced acute nephrotoxicity rat models, it was found that the treatment with L-theanine could attenuate the decrease of creatinine clearance, inhibit the production of lipid peroxidation in the kidney, and inhibit the reduction of glutathione content and SOD activity after DOX administration (90)

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In line with these results, in a previous work we observed an AMPH-induced increase of vascular tortuosity in PL-PFC together with less branching points and an increased microvessels occupied area (Figure 7