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All authors participated in writing the first draft of the manuscript

PCR conditions were as following: initial denaturation at 95 C for 5 min, followed by 37 cycles of denaturation (94 C for 40 s), annealing (57 C for 30 s) and extension (72 C for 40 s), with the final extension at 72 C for 10 min

Remarkably, in both animal models and cell investigations, RF deprivation has been linked to the prevention of tumor growth (94) ( Table 2 )