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Dutta D, et al

This enzyme catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor, effectively creating a "metabolic drain" that depletes both NAD+ precursors and cellular methylation capacity

J., & Sluka, K

symptom management and orthotic support AFO for foot drop (L-code orthoses), custom footwear, surgery for foot deformity (pes cavus correction) Genetic counseling: document gene mutation identified (PMP22 duplication CMT1A, GJB1 CMTX, MFN2 CMT2A) Avoid neurotoxic drugs (vincristine, colchicine) document CMT diagnosis prominently in medication reconciliation Patient Education / Summary Patient education documentation supports coding specificity and demonstrates active management of neuropathy complications