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There have been reports of pleural and retroperitoneal fibrosis in patients following prolonged daily use of injectable dihydroergotamine mesylate

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First of all, baseline folic acid levels were different between studies (7.7 ng/mL for CSPPT renal sub study, 15 and 16.5 ng/mL for DIVINe and HOST study respectively) corroborating the hypothesis that beneficial effects of folic acid supplementation on renal outcomes could be stronger in patients with low folic acid level at baseline

While some experience noticeable shedding, others report no changes in their hair