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Although postload homocysteine measurements were not carried out, the stronger relationship in women might be partially caused by a more efficient transsulfuration in men, who present a lower response to the methionine overload than women at age-specific ranges (Silberberg et al, 1997)

Here is how patients typically describe the difference: Energy Before SS-31: experiencing energy crashes in the afternoon, reliance on caffeine to maintain function, feeling wiped out after moderate activity, waking unrefreshed despite adequate sleep hours