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In another study, when mouse Hepa1c1c7 cells were incubated with 25 m SFN, an increase in NAD(P)H:quinone oxidoreductase 1 activity was observed, reaching a maximum induction of three-fold over control ( Reference Matusheski and Jeffery 21 )

In patients with active RA, the addition of low-dose sirolimus (0.5 mg every other day for 24 weeks) to conventional immunosuppressive therapy effectively increased Treg cell frequencies, reduced Th17 cell populations, and improved clinical disease activity (Chictr.org.cn identifier: ChiCTR-IPR-17010307) (240)